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CS-W001157 4
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3-Bromo-2-fluoro-6-methoxybenzaldehyde

  • CAS No. 1160653-94-0

  • Cat. No. CS-0195367
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluoro-6-methoxybenzaldehyde|CS-0195367

Structure of 1160653-94-0

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General Information

  • CAS No. 1160653-94-0
  • Cat. No. CS-0195367
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₂
  • Molecular Weight 233.03
  • Synonym(s) 3-bromo-2-fluoro-6-methoxy-benzaldehyde
  • SMILES COC1=CC=C(C(=C1C=O)F)Br

Description

3-Bromo-2-fluoro-6-methoxybenzaldehyde features a trifunctional aromatic core with bromine, fluorine, and methoxy substituents positioned ortho to the aldehyde group. This electron-deficient benzaldehyde integrates readily into cross-coupling reactions and serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science.

Application

3-Bromo-2-fluoro-6-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The aldehyde functionality facilitates imine formation and reductive amination, while the methoxy and fluorine substituents provide orthogonal handle options for further functionalization. Bench-stable and compatible with standard purification protocols, it supports scalable synthesis of complex heterocyclic scaffolds and bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.4093
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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