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CS-W001157 4
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2,5-Dichlorobenzaldehyde

  • CAS No. 6361-23-5

  • Cat. No. CS-W017472
  • Purity≥97%
  • MDL No.MFCD00156140

*For research and further manufacturing use only, not for direct human use.

2,5-Dichlorobenzaldehyde|CS-W017472

Structure of 6361-23-5

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General Information

  • CAS No. 6361-23-5
  • Cat. No. CS-W017472
  • Purity ≥97%
  • MDL No. MFCD00156140
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂O
  • Molecular Weight 175.01
  • Synonym(s) 2,5-Dichloro Benzaldehdye; 2,5-Dichlorobenzaldehyde
  • SMILES O=CC1=CC(Cl)=CC=C1Cl

Description

2,5-Dichlorobenzaldehyde features a rigid aromatic core bearing two chlorine substituents at the 2- and 5-positions, enhancing its electron-deficient character. This configuration supports efficient electrophilic substitution and facilitates incorporation into heterocyclic systems. The aldehyde group enables direct coupling reactions, offering a stable, moisture-tolerant handle for synthetic applications in medicinal chemistry and materials science.

Application

2,5-Dichlorobenzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling the construction of heterocyclic scaffolds and functionalized aryl systems. Its ortho-dichloro substitution pattern provides enhanced electrophilicity at the carbonyl center while maintaining bench stability and compatibility with common coupling reactions. The molecule facilitates efficient derivatization via nucleophilic addition, Ullmann-type couplings, and transition-metal-catalyzed transformations, making it valuable for medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Sindelar; Metysova; Holubek; et al. Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 11 p. 3077 - 3093
  • Route2
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      2745-49-5
    • ~%
    • In-stock
      2,5-Dichlorobenzaldehyde|CS-W017472
      6361-23-5

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 47, # 11 p. 3077 - 3093
  • Route3
    • null|null
      3084-17-1
    • ~%
    • In-stock
      2,5-Dichlorobenzaldehyde|CS-W017472
      6361-23-5

    References

    • Bulletin of the Chemical Society of Japan, , vol. 41, # 2 p. 424 - 429

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8059
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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