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CS-W001157 4
Total: USD 88.00

NSC 28450

  • CAS No. 6334-18-5

  • Cat. No. CS-W018532
  • Purity≥98%
  • MDL No.MFCD00010127

*For research and further manufacturing use only, not for direct human use.

NSC 28450|CS-W018532

Structure of 6334-18-5

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General Information

  • CAS No. 6334-18-5
  • Cat. No. CS-W018532
  • Purity ≥98%
  • MDL No. MFCD00010127
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂O
  • Molecular Weight 175.01
  • Synonym(s) 2,3-Dichlorobenzaldehyde
  • SMILES O=CC1=CC=CC(Cl)=C1Cl

Description

2,3-Dichlorobenzaldehyde has been used in preparation of:4-(2,3-dichlorobenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, Schiff baseethyl 4-(2,3-dichlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate via Biginelli condensationbenzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Application

2,3-Dichlorobenzaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic research. Its ortho-dichloro substitution pattern enhances electrophilicity at the carbonyl center while providing robust stability under standard reaction conditions. The molecule facilitates efficient coupling reactions, including Wittig, Grignard, and nucleophilic additions, and functions as a key intermediate in the synthesis of heterocyclic scaffolds and functionalized aromatic compounds.

Synthesis

  • Route1
    • (E)-2,3-dichlorobenzaldehyde oxime|CS-0452536
      4414-54-4
    • ~82%
    • In-stock
      NSC 28450|CS-W018532
      6334-18-5

    References

    • Bose, D. Subhas; Venkat Narasaiah Synthetic Communications, 2000 , vol. 30, # 6 p. 1153 - 1158
  • Route2
    • null|null
      288-43-7
    • In-stock
      3-Aminopyrazole|CS-D1141
      1820-80-0
    • 3,4-Dichlorobenzaldehyde Ixazomib  Impurity|CS-0228770
      6287-38-3
    • ~%
    • In-stock
      NSC 28450|CS-W018532
      6334-18-5

    References

    • US2003/22890 A1, ; US 20030022890 A1
  • Route3
    • null|null
      32768-54-0
    • ~%
    • In-stock
      NSC 28450|CS-W018532
      6334-18-5

    References

    • Journal of the American Chemical Society, , vol. 68, p. 861,863 Industrial and Engineering Chemistry, , vol. 39, p. 1486,1487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8059
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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