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CS-W001157 4
Total: USD 88.00

2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 635305-47-4

  • Cat. No. CS-0004330
  • Purity≥97%
  • MDL No.MFCD05663877

*For research and further manufacturing use only, not for direct human use.

2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0004330

Structure of 635305-47-4

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General Information

  • CAS No. 635305-47-4
  • Cat. No. CS-0004330
  • Purity ≥97%
  • MDL No. MFCD05663877
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆BClO₂
  • Molecular Weight 238.52
  • Synonym(s) 3-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
  • SMILES CC1(C)C(C)(C)OB(C2=CC=CC(Cl)=C2)O1

Description

This boronate ester features a 3-chlorophenyl group appended to a tetramethyl-substituted dioxaborolane ring, delivering enhanced stability and compatibility with Suzuki-Miyaura cross-coupling reactions. The electron-deficient aryl moiety enables efficient palladium-catalyzed transformations under standard conditions.

Synthesis

  • Route1
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      456-39-3
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    • In-stock
      2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0004330
      635305-47-4

    References

    • UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel Patent: WO2014/9169 A1, 2014 ; Location in patent: Page/Page column 53-54; 67-68 ;
  • Route2

    References

    • NOVO NORDISK A/S Patent: WO2003/105860 A1, 2003 ; Location in patent: Page 34-35 ; WO 03/105860 A1
  • Route3
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      1-Chloro-3-iodobenzene,98% (stabilized with Cu)|CS-W007365
      625-99-0
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      61676-62-8
    • ~97%
    • In-stock
      2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0004330
      635305-47-4

    References

    • Browne, Duncan L.; Baumann, Marcus; Harji, Bashir H.; Baxendale, Ian R.; Ley, Steven V. Organic Letters, 2011 , vol. 13, # 13 p. 3312 - 3315

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.6392
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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