4-(4-Bromophenyl)morpholin-3-one

Name: 4-(4-Bromophenyl)morpholin-3-one
Brand: ChemScene
Availability: InStock
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CAS No. 634905-12-7
Cat. No. CS-0322755
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-(4-Bromophenyl)morpholin-3-one|CS-0322755

Structure of 634905-12-7

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General Information

CAS No. 634905-12-7
Cat. No. CS-0322755
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀BrNO₂
Molecular Weight 256.10
Synonym(s) 3-Morpholinone,4-(4-bromophenyl)
SMILES O=C1N(C2=CC=C(Br)C=C2)CCOC1

Description

4-(4-Bromophenyl)morpholin-3-one features a brominated phenyl group fused to a morpholinone core, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient access to bioactive compounds through coupling reactions under standard conditions.

Application

4-(4-Bromophenyl)morpholin-3-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of biologically relevant scaffolds. The brominated aryl group facilitates palladium-catalyzed cross-coupling reactions, while the morpholinone core provides a stable, polar heterocyclic framework with favorable solubility and metabolic stability. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for iterative synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  109-11-5
- In-stock
  
  106-37-6
- ~68%
- In-stock
  
  634905-12-7
References
- BRISTOL-MYERS SQUIBB COMPANY; WROBLESKI, Stephen T.; JAGABANDHU, Das; DOWEYKO, Lidia M.; GUO, Junqing; HYNES, John; JIANG, Bin; KEMPSON, James; LIN, Shuqun; SPERGEL, Steven H.; TOKARSKI, John S.; WU, Hong; YANG, Bingwei Vera Patent: WO2012/125887 A1, 2012 ; Location in patent: Page/Page column 128-129 ; WO 2012/125887 A1
Route2
- In-stock
  
  30483-75-1
- ~35%
- In-stock
  
  634905-12-7
References
- BAYER HEALTHCARE AG Patent: WO2003/104227 A1, 2003 ; Location in patent: Page 53 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 29.54
LogP 1.8123
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(4-Bromophenyl)morpholin-3-one

CAS No. 634905-12-7

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