Lot numbers can be found on the outside label of a product:
Rivaroxaban impurity 48
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CAS No. 109-11-5
- Cat. No. CS-D1427
- Purity≥97%
- MDL No.MFCD00631009
*For research and further manufacturing use only, not for direct human use.
Structure of 109-11-5
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General Information
- CAS No. 109-11-5
- Cat. No. CS-D1427
- Purity ≥97%
- MDL No. MFCD00631009
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₇NO₂
- Molecular Weight 101.11
- Synonym(s) None
- SMILES O=C1NCCOC1
Description
3-Ketomorpholine features a carbonyl group at the C3 position of the morpholine ring, enhancing electrophilicity for targeted conjugate additions. This functionalized scaffold integrates readily into complex heterocycles and serves as a pivotal building block in medicinal chemistry. The ketone moiety enables selective derivatization under mild conditions, supporting efficient synthesis of bioactive analogs.
Application
3-Ketomorpholine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to morpholine-based heterocycles and bioactive scaffolds. Its ketone functionality facilitates nucleophilic addition, reductive amination, and condensation reactions under standard conditions. The compound exhibits good bench stability and compatibility with common protecting groups, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
Synthesis
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Route1
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141-43-5 -
105-39-5
- ~34%
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In-stock
109-11-5
References
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Kuwano, Satoru; Harada, Shingo; Oriez, Raphael; Yamada, Ken-Ichi Chemical Communications, 2012 , vol. 48, # 1 p. 145 - 147
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Route2
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6320-16-7
- ~10%
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In-stock
109-11-5
References
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JAPAN TOBACCO INC. Patent: US2011/306599 A1, 2011 ; Location in patent: Page/Page column 35 ;
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Route3
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75-39-8
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105-39-5
- ~%
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In-stock
109-11-5
References
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WO2006/55951 A2, ; Page/Page column 44 ; WO 2006/055951 A2
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.33
- LogP -0.8672
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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