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CS-W001157 4
Total: USD 88.00

3-(2-Methoxyphenyl)propanoic acid

  • CAS No. 6342-77-4

  • Cat. No. CS-W017211
  • Purity≥98%
  • MDL No.MFCD00002772

*For research and further manufacturing use only, not for direct human use.

3-(2-Methoxyphenyl)propanoic acid|CS-W017211

Structure of 6342-77-4

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General Information

  • CAS No. 6342-77-4
  • Cat. No. CS-W017211
  • Purity ≥98%
  • MDL No. MFCD00002772
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₃
  • Molecular Weight 180.20
  • Synonym(s) O-METHOXYHYDROCINNAMIC ACID
  • SMILES O=C(O)CCC1=CC=CC=C1OC

Description

This 3-(2-methoxyphenyl)propanoic acid features a benzene ring bearing a methoxy substituent at the ortho position, integrated with a propanoic acid chain. The electron-donating methoxy group enhances solubility and influences reactivity in coupling processes. The carboxylic acid moiety enables direct functionalization or salt formation for improved handling.

Application

3-(2-Methoxyphenyl)propanoic acid serves as a versatile building block for bioactive molecule synthesis, enabling efficient access to phenylpropanoid scaffolds. Its ortho-methoxyaryl group provides enhanced stability and favorable electronic properties for downstream functionalization. The carboxylic acid moiety facilitates coupling reactions, esterifications, and amide formations under standard conditions, offering reliable reactivity and straightforward purification.

Synthesis

  • Route1

    References

    • Ghosh, Somnath; Datta, Indira; Chakraborty, Rupak; Das, Tapas Kumar; Sengupta, Judhajit; Sarkar, Dipak Chandra Tetrahedron, 1989 , vol. 45, # 5 p. 1441 - 1446
  • Route2

    References

    • Lim, Minkyung; De Castro, Kathlia A.; Oh, Seungchan; Lee, Kangsuk; Chang, Young-Wook; Kim, Hokun; Rhee, Hakjune Applied Organometallic Chemistry, 2011 , vol. 25, # 1 p. 1 - 8
  • Route3

    References

    • Hayashi, Masahiko; Kawabata, Hirotoshi; Yoshimoto, Kazuya; Tanaka, Takanori Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 2 p. 433 - 445

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.7124
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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