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CS-W001157 4
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Dimethyl 2-hydroxyterephthalate

  • CAS No. 6342-72-9

  • Cat. No. CS-0150841
  • Purity≥98%
  • MDL No.MFCD08445666

*For research and further manufacturing use only, not for direct human use.

Dimethyl 2-hydroxyterephthalate|CS-0150841

Structure of 6342-72-9

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General Information

  • CAS No. 6342-72-9
  • Cat. No. CS-0150841
  • Purity ≥98%
  • MDL No. MFCD08445666
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₅
  • Molecular Weight 210.18
  • Synonym(s) dimethyl 2-hydroxybenzene-1,4-dicarboxylate
  • SMILES COC(=O)C1=CC(=C(C=C1)C(=O)OC)O

Description

Dimethyl 2-hydroxyterephthalate features a hydroxyl-substituted aromatic core paired with two ester functionalities, enabling direct integration into polycondensation reactions. This bench-stable diester serves as a key monomer for synthesizing high-performance polyesters and functionalized polymers under standard conditions.

Application

Dimethyl 2-hydroxyterephthalate serves as a versatile diester building block for the synthesis of functionalized aromatic scaffolds. The ortho-hydroxyl group enables direct metal-catalyzed coupling reactions and facilitates downstream derivatization via ester hydrolysis or etherification. Its bench-stable, crystalline nature supports straightforward handling and purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials development.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      2-Hydroxyterephthalic acid|CS-W009063
      636-94-2
    • ~97%
    • In-stock
      Dimethyl 2-hydroxyterephthalate|CS-0150841
      6342-72-9

    References

    • Tanabe, Kristine K.; Allen, Corinne A.; Cohen, Seth M. Angewandte Chemie - International Edition, 2010 , vol. 49, # 50 p. 9730 - 9733
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 128, # 36 p. 11940 - 11947
  • Route3

    References

    • Yang, Yiqing; Lin, Yun; Rao, Yu Organic Letters, 2012 , vol. 14, # 11 p. 2874 - 2877

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   72.83
  • LogP   0.9654
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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