2,5-Dioxopyrrolidin-1-yl 6-acrylamidohexanoate

Name: 2,5-Dioxopyrrolidin-1-yl 6-acrylamidohexanoate
Brand: ChemScene
Availability: InStock
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CAS No. 63392-86-9
Cat. No. CS-0163155
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,5-Dioxopyrrolidin-1-yl 6-acrylamidohexanoate|CS-0163155

Structure of 63392-86-9

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Description

This acrylamide-functionalized active ester enables efficient conjugation in bioorthogonal labeling workflows. The 2,5-dioxopyrrolidin-1-yl group delivers high reactivity toward amines under physiological conditions, while the six-carbon spacer provides optimal flexibility for probe design. Designed for robust coupling in protein and peptide modification.

Application

2,5-Dioxopyrrolidin-1-yl 6-acrylamidohexanoate serves as a versatile acrylamide-containing active ester, enabling efficient amide bond formation under mild conditions. The acrylamide functionality provides orthogonal reactivity for downstream conjugation, while the pyrrolidinone ester moiety ensures excellent stability and clean reaction profiles. This reagent facilitates rapid peptide and bioconjugate synthesis with high yields and straightforward purification, making it ideal for bench-scale applications in medicinal chemistry and protein labeling workflows.

General Information

CAS No. 63392-86-9
Cat. No. CS-0163155
Purity ≥96%
MDL No. None
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₈N₂O₅
Molecular Weight 282.29
Synonym(s) N-Succinimidyl 6-Acrylamidohexanoate
SMILES O=C(ON1C(CCC1=O)=O)CCCCCNC(C=C)=O

Computational Chemistry Data

TPSA 92.78
LogP 0.4562
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 8

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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2,5-Dioxopyrrolidin-1-yl 6-acrylamidohexanoate

CAS No. 63392-86-9

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