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CS-W001157 4
Total: USD 88.00

(E)-2-(3-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 633327-36-3

  • Cat. No. CS-0527635
  • Purity≥96%
  • MDL No.MFCD19703877

*For research and further manufacturing use only, not for direct human use.

(E)-2-(3-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0527635

Structure of 633327-36-3

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General Information

  • CAS No. 633327-36-3
  • Cat. No. CS-0527635
  • Purity ≥96%
  • MDL No. MFCD19703877
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BFO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(/C=C/C2=CC=CC(F)=C2)O1

Description

(E)-2-(3-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a bench-stable boronate reagent featuring an electron-deficient vinyl group. This configuration enables efficient Suzuki-Miyaura coupling under standard conditions, delivering conjugated aryl fluorides with high regioselectivity and minimal side-product formation.

Application

(E)-2-(3-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The (E)-configured vinylboronate enables stereoselective construction of conjugated styrenyl systems with excellent functional group tolerance. Its tetramethyl-substituted dioxaborolane ring enhances stability and facilitates purification, making it ideal for scalable synthesis of fluorinated aromatic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.4703
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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