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CS-W001157 4
Total: USD 88.00

4-Methylbenzimidamide hydrochloride

  • CAS No. 6326-27-8

  • Cat. No. CS-W010775
  • Purity≥97%
  • MDL No.MFCD00040183

*For research and further manufacturing use only, not for direct human use.

4-Methylbenzimidamide hydrochloride|CS-W010775

Structure of 6326-27-8

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General Information

  • CAS No. 6326-27-8
  • Cat. No. CS-W010775
  • Purity ≥97%
  • MDL No. MFCD00040183
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClN₂
  • Molecular Weight 170.64
  • Synonym(s) amino(4-methylphenyl)methaniminium
  • SMILES CC1=CC=C(C(N)=N)C=C1.Cl

Description

4-Methylbenzimidamide hydrochloride offers a stable, moisture-tolerant platform for medicinal chemistry applications. The compound features a methyl-substituted benzimidamide core with enhanced solubility in aqueous and polar organic solvents, enabling straightforward integration into reaction workflows. This form facilitates efficient coupling and derivatization under standard bench conditions.

Application

4-Methylbenzimidamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of benzimidazole-based scaffolds prevalent in kinase inhibitors and bioactive heterocycles. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into complex molecules, while the protonated amine enhances solubility and purification via salt formation.

Synthesis

  • Route1
    • null|null
      104-85-8
    • ~79%
    • In-stock
      4-Methylbenzimidamide hydrochloride|CS-W010775
      6326-27-8

    References

    • Brown; Cronin; Lan; Nardo Australian Journal of Chemistry, 1985 , vol. 38, # 5 p. 825 - 833
  • Route2
    • null|null
      72525-60-1
    • null|null
      104-85-8
    • ~1%
    • In-stock
      4-Methylbenzimidamide hydrochloride|CS-W010775
      6326-27-8

    References

    • Emura, Takashi; Haneishi, Tsuyoshi Patent: US2003/158442 A1, 2003 ;
  • Route3

    References

    • Mahajan, Umesh S.; Godinde, Rupesh R.; Mandhare Synthetic Communications, 2011 , vol. 41, # 15 p. 2195 - 2199

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.87
  • LogP   1.70089
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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