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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-oxo-3-phenylpiperidine-1-carboxylate

  • CAS No. 632352-56-8

  • Cat. No. CS-W018956
  • Molecule weight275.34
  • Purity≥97%
  • MDL No.MFCD08669341

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-oxo-3-phenylpiperidine-1-carboxylate|CS-W018956

Structure of 632352-56-8

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General Information

  • CAS No. 632352-56-8
  • Cat. No. CS-W018956
  • Purity ≥97%
  • MDL No. MFCD08669341
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₁NO₃
  • Molecular Weight 275.34
  • Synonym(s) 1-Boc-3-phenylpiperidin-4-one
  • SMILES CC(C)(C)OC(=O)N1CCC(=O)C(C1)C1=CC=CC=C1

Description

tert-Butyl 4-oxo-3-phenylpiperidine-1-carboxylate features a sterically hindered tert-butyl ester and a conjugated ketone, enabling direct functionalization at the C4 position. The phenyl group enhances π-stacking potential in molecular scaffolds, while the bench-stable carbamate facilitates modular synthesis of bioactive piperidines under standard conditions.

Application

tert-Butyl 4-oxo-3-phenylpiperidine-1-carboxylate serves as a versatile scaffold for the synthesis of biologically relevant piperidine derivatives. The ketone functionality enables enolate formation and nucleophilic addition, while the tert-butoxycarbonyl group offers convenient protection and orthogonal deprotection. Its stability under standard reaction conditions facilitates functionalization at C4 and C3 positions, supporting applications in medicinal chemistry and heterocycle construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.9801
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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