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CS-W001157 4
Total: USD 88.00

1-(2-Chlorophenyl)propan-1-one

  • CAS No. 6323-18-8

  • Cat. No. CS-B1195
  • Purity≥97%
  • MDL No.MFCD07787256

*For research and further manufacturing use only, not for direct human use.

1-(2-Chlorophenyl)propan-1-one|CS-B1195

Structure of 6323-18-8

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General Information

  • CAS No. 6323-18-8
  • Cat. No. CS-B1195
  • Purity ≥97%
  • MDL No. MFCD07787256
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉ClO
  • Molecular Weight 168.62
  • Synonym(s) 2'-Chloropropiophenone; o-Chloropropiophenone; 2-Chlorophenyl Ethyl Ketone
  • SMILES CCC(C1=CC=CC=C1Cl)=O

Description

This 1-(2-chlorophenyl)propan-1-one features a chlorinated aromatic ring paired with a ketone-functionalized alkyl chain, enabling direct incorporation into synthetic pathways requiring electron-deficient aryl groups. The molecule exhibits robust stability under standard bench conditions and facilitates efficient coupling reactions in pharmaceutical intermediates and functional materials.

Application

1-(2-Chlorophenyl)propan-1-one serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient construction of biologically relevant scaffolds. Its aryl ketone functionality supports electrophilic functionalization, Grignard additions, and reductive transformations under standard conditions. The ortho-chloro substituent enhances metabolic stability and provides a handle for further derivatization via cross-coupling reactions. Bench-stable and readily purified by recrystallization, it functions reliably in multistep syntheses and process development workflows.

Synthesis

  • Route1
    • 1-(2-Chlorophenyl)propan-1-ol|CS-0378148
      22869-35-8
    • ~99%
    • In-stock
      1-(2-Chlorophenyl)propan-1-one|CS-B1195
      6323-18-8

    References

    • Inamoto, Kiyofumi; Katsuno, Mika; Yoshino, Takashi; Arai, Yukari; Hiroya, Kou; Sakamoto, Takao Tetrahedron, 2007 , vol. 63, # 12 p. 2695 - 2711
  • Route2
    • In-stock
      2-Chlorobenzonitrile|CS-W018317
      873-32-5
    • null|null
      925-90-6
    • ~87%
    • In-stock
      1-(2-Chlorophenyl)propan-1-one|CS-B1195
      6323-18-8

    References

    • Messali, Mouslim; Christiaens, Leon E.; Alshahateet, Solhe F.; Kooli, Fethi Tetrahedron Letters, 2007 , vol. 48, # 42 p. 7448 - 7451
  • Route3
    • 1-(2-Aminophenyl)propan-1-one|CS-0215393
      1196-28-7
    • ~%
    • In-stock
      1-(2-Chlorophenyl)propan-1-one|CS-B1195
      6323-18-8

    References

    • Journal of Organic Chemistry, , vol. 11, p. 444,447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.9327
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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