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CS-W001157 4
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1-(Thiophen-2-yl)ethanamine

  • CAS No. 6309-16-6

  • Cat. No. CS-W016558
  • Purity≥98%
  • MDL No.MFCD02734311

*For research and further manufacturing use only, not for direct human use.

1-(Thiophen-2-yl)ethanamine|CS-W016558

Structure of 6309-16-6

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General Information

  • CAS No. 6309-16-6
  • Cat. No. CS-W016558
  • Purity ≥98%
  • MDL No. MFCD02734311
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NS
  • Molecular Weight 127.21
  • Synonym(s) 2-(3-Pyridinyl)azepane
  • SMILES CC(N)C1=CC=CS1

Description

1-(Thiophen-2-yl)ethanamine features a thiophene ring directly linked to an ethylamine side chain, delivering a robust heteroaromatic scaffold with enhanced solubility and stability. This moiety integrates readily into bioactive molecules, particularly in medicinal chemistry applications where electron-rich aromatic systems improve target affinity. The amine group enables straightforward derivatization under standard conditions.

Application

1-(Thiophen-2-yl)ethanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard amine functionalization. Its thiophene moiety provides enhanced metabolic stability and π-stacking potential, while the primary amine facilitates straightforward conjugation, reductive amination, and peptide coupling. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • CYTOPIA RESEARCH PTY LTD Patent: WO2005/54230 A1, 2005 ; Location in patent: Page/Page column 37-38 ; WO 2005/054230 A1
  • Route2
    • 1-(Thiophen-2-yl)ethan-1-one oxime|CS-1720169
      1956-45-2
    • ~%
    • In-stock
      1-(Thiophen-2-yl)ethanamine|CS-W016558
      6309-16-6

    References

    • Zhurnal Obshchei Khimii, , vol. 18, p. 1866,1867 Chem.Abstr., , p. 3817

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.7678
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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