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CS-W001157 4
Total: USD 88.00

2-Methoxy-6-methylpyridine

  • CAS No. 63071-03-4

  • Cat. No. CS-W003150
  • Purity≥98%
  • MDL No.MFCD04112507

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-6-methylpyridine|CS-W003150

Structure of 63071-03-4

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General Information

  • CAS No. 63071-03-4
  • Cat. No. CS-W003150
  • Purity ≥98%
  • MDL No. MFCD04112507
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight None
  • Synonym(s) 6-Methoxy-2-picoline; 2-Methoxy-6-methylpyridine
  • SMILES CC1=NC(OC)=CC=C1

Description

2-Methoxy-6-methylpyridine is a bench-stable, electron-rich heterocycle featuring a methoxy group at the 2-position and a methyl substituent at the 6-position. This combination enhances solubility and directs electrophilic substitution selectively. The compound serves as a key scaffold in medicinal chemistry and catalyst design, offering predictable reactivity under standard conditions.

Application

2-Methoxy-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds through electrophilic substitution and transition-metal-catalyzed coupling reactions. Its ortho-substituted structure provides enhanced stability and predictable regiochemistry, while the methoxy and methyl groups offer complementary functional handles for further derivatization. The compound exhibits excellent bench stability and is readily purified by distillation or chromatography, making it well-suited for scalable synthesis and API development workflows.

Synthesis

  • Route1
    • In-stock
      6-Methylpyridin-2(1H)-one|CS-W011283
      3279-76-3
    • null|null
      74-88-4
    • ~99%
    • In-stock
      2-Methoxy-6-methylpyridine|CS-W003150
      63071-03-4

    References

    • Brodney, Michael A.; Padwa, Albert Tetrahedron Letters, 1997 , vol. 38, # 35 p. 6153 - 6156
  • Route2
    • In-stock
      6-Methylpyridin-2(1H)-one|CS-W011283
      3279-76-3
    • null|null
      420-37-1
    • ~26%
    • In-stock
      2-Methoxy-6-methylpyridine|CS-W003150
      63071-03-4

    References

    • Pfizer Inc. Patent: US6251904 B1, 2001 ;
  • Route3

    References

    • US2003/125330 A1, ; US 20030125330 A1

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.39862
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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