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CS-W001157 4
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L-tert-Leucine Methyl Ester Hydrochloride

  • CAS No. 63038-27-7

  • Cat. No. CS-M1884
  • Purity≥97%
  • MDL No.MFCD00040604

*For research and further manufacturing use only, not for direct human use.

L-tert-Leucine Methyl Ester Hydrochloride|CS-M1884

Structure of 63038-27-7

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General Information

  • CAS No. 63038-27-7
  • Cat. No. CS-M1884
  • Purity ≥97%
  • MDL No. MFCD00040604
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆ClNO₂
  • Molecular Weight 181.66
  • Synonym(s) None
  • SMILES N[C@@H](C(C)(C)C)C(OC)=O.[H]Cl

Description

L-tert-Leucine Methyl Ester Hydrochloride offers a sterically hindered side chain ideal for probing conformational constraints in peptide design. The methyl ester group enables direct incorporation into peptide chains, while the hydrochloride salt enhances solubility and handling under standard conditions. This derivative serves as a valuable building block in synthetic peptide chemistry.

Application

L-tert-Leucine Methyl Ester Hydrochloride serves as a valuable chiral building block in peptide synthesis, offering enhanced stability and solubility compared to its free amine counterpart. The hydrochloride salt form facilitates handling and purification, while the tert-leucine side chain provides steric hindrance useful in modulating peptide conformation and metabolic resistance. This derivative enables efficient incorporation into peptidomimetics and bioactive scaffolds through standard coupling protocols.

Synthesis

  • Route1
    • null|null
      67-56-1
    • (S)-2-Amino-3,3-dimethylbutanoic acid hydrochloride|CS-0162061
      139163-43-2
    • ~%
    • In-stock
      L-tert-Leucine Methyl Ester Hydrochloride|CS-M1884
      63038-27-7

    References

    • European Journal of Medicinal Chemistry, , vol. 68, p. 253 - 259
  • Route2
    • null|null
      67-56-1
    • In-stock
      (S)-2-Amino-3,3-dimethylbutanoic acid|CS-D0917
      20859-02-3
    • ~95%
    • In-stock
      L-tert-Leucine Methyl Ester Hydrochloride|CS-M1884
      63038-27-7

    References

    • Griesbeck, Axel G.; Mauder, Harald Angewandte Chemie, 1992 , vol. 104, # 1 p. 97 - 99
  • Route3
    • null|null
      75158-11-1
    • ~%
    • In-stock
      L-tert-Leucine Methyl Ester Hydrochloride|CS-M1884
      63038-27-7

    References

    • Helvetica Chimica Acta, , vol. 63, # 4 p. 824 - 831

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.9546
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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