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CS-W001157 4
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1-(4-Methoxyphenyl)ethylamine

  • CAS No. 6298-96-0

  • Cat. No. CS-0154100
  • Purity≥98%
  • MDL No.MFCD00044523

*For research and further manufacturing use only, not for direct human use.

1-(4-Methoxyphenyl)ethylamine|CS-0154100

Structure of 6298-96-0

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General Information

  • CAS No. 6298-96-0
  • Cat. No. CS-0154100
  • Purity ≥98%
  • MDL No. MFCD00044523
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO
  • Molecular Weight 151.21
  • Synonym(s) Benzenemethanamine, 4-methoxy-alpha-methyl-
  • SMILES CC(C1=CC=C(C=C1)OC)N

Description

1-(4-Methoxyphenyl)ethylamine features a phenethylamine scaffold with a para-methoxy substituent, delivering enhanced solubility and metabolic stability. This bench-stable amine integrates readily into bioactive molecule synthesis, serving as a key building block for pharmaceutical intermediates and functionalized materials.

Application

1-(4-Methoxyphenyl)ethylamine serves as a versatile building block for pharmaceutical intermediates and agrochemical scaffolds. Its benzylic amine functionality enables straightforward derivatization via alkylation, acylation, and reductive amination. The para-methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—ideal for iterative synthesis in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      143589-99-5
    • ~%
    • In-stock
      1-(4-Methoxyphenyl)ethylamine|CS-0154100
      6298-96-0

    References

    • US5438118 A1, ; US 5438118 A
  • Route2
    • null|null
      1034926-69-6
    • ~76%
    • In-stock
      1-(4-Methoxyphenyl)ethylamine|CS-0154100
      6298-96-0

    References

    • Laczkowski, Krzysztof Z.; Pakulski, Marcin M.; Krzeminski, Marek P.; Jaisankar, Parasuraman; Zaidlewicz, Marek Tetrahedron Asymmetry, 2008 , vol. 19, # 7 p. 788 - 795
  • Route3
    • In-stock
      4-Methoxyacetophenone|CS-0008322
      100-06-1
    • ~%
    • In-stock
      1-(4-Methoxyphenyl)ethylamine|CS-0154100
      6298-96-0
    • In-stock
      1-(4-Methoxyphenyl)ethylamine|CS-0154100
      6298-96-0

    References

    • Angewandte Chemie - International Edition, , vol. 42, # 44 p. 5472 - 5474

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.7149
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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