Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Chloro-3-(trifluoromethyl)phenol

  • CAS No. 6294-93-5

  • Cat. No. CS-W015692
  • Purity≥98%
  • MDL No.MFCD00042525

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-(trifluoromethyl)phenol|CS-W015692

Structure of 6294-93-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6294-93-5
  • Cat. No. CS-W015692
  • Purity ≥98%
  • MDL No. MFCD00042525
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClF₃O
  • Molecular Weight 196.55
  • Synonym(s) 2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE
  • SMILES OC1=CC=C(Cl)C(C(F)(F)F)=C1

Description

4-Chloro-3-(trifluoromethyl)phenol features a trifluoromethyl group flanking a chlorinated aromatic ring, delivering enhanced electron-withdrawal and metabolic stability. This configuration supports direct functionalization in cross-coupling reactions and facilitates integration into bioactive scaffolds requiring halogen-directed reactivity. The compound exhibits robust bench stability and compatibility with diverse reaction conditions.

Application

4-Chloro-3-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl group and ortho-chlorine site. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chlorine facilitates palladium-catalyzed cross-coupling reactions. The compound exhibits good bench stability and compatibility with standard purification methods, making it ideal for constructing complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • 4-Chloro-3-(trifluoromethyl)aniline  Regorafenib Impurity|CS-0166941
      320-51-4
    • ~%
    • In-stock
      4-Chloro-3-(trifluoromethyl)phenol|CS-W015692
      6294-93-5

    References

    • Journal of the American Chemical Society, , vol. 73, p. 3470 US2489423 , ; DE884196 , ; DRP/DRBP Org.Chem.
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 73, p. 3470

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.0644
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Chloro-3-(trifluoromethyl)phenol sigma4-Chloro-3-(trifluoromethyl)phenol manufacturer4-Chloro-3-(trifluoromethyl)phenol price4-Chloro-3-(trifluoromethyl)phenol structure4-Chloro-3-(trifluoromethyl)phenol SDSbuy 4-Chloro-3-(trifluoromethyl)phenol4-Chloro-3-(trifluoromethyl)phenol supplier4-Chloro-3-(trifluoromethyl)phenol uses4-Chloro-3-(trifluoromethyl)phenol molecular weightprice of 4-Chloro-3-(trifluoromethyl)phenol4-Chloro-3-(trifluoromethyl)phenol chemical name formula of 4-Chloro-3-(trifluoromethyl)phenol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label