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Structure of 628732-07-0
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5-Fluoro-2,3-dihydro-1H-indene-2-carboxylic acid features a fluorinated indene core with a carboxylic acid group at the 2-position, offering enhanced metabolic stability and lipophilicity. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors. The electron-withdrawing fluorine substituent modulates electronic distribution across the aromatic system, improving binding affinity in target-directed designs.
5-Fluoro-2,3-dihydro-1H-indene-2-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated indane scaffolds prevalent in bioactive molecules. Its carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl chloride formation, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard coupling conditions, supporting efficient incorporation into diverse synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: