6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid

Name: 6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 920501-51-5
Cat. No. CS-0461793
Purity≥98%
MDL No.MFCD11219727

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid|CS-0461793

Structure of 920501-51-5

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General Information

CAS No. 920501-51-5
Cat. No. CS-0461793
Purity ≥98%
MDL No. MFCD11219727
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₉FO₂
Molecular Weight 180.18
Synonym(s) None
SMILES O=C(O)C1C2=CC(F)=CC=C2CC1

Description

6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid features a fluorinated indene core with a carboxylic acid group at the 1-position, delivering enhanced metabolic stability and lipophilicity. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid serves as a valuable synthetic building block for medicinal chemistry and heterocyclic scaffold development. Its fluorinated indane core provides enhanced metabolic stability and modulated lipophilicity, while the carboxylic acid functionality enables straightforward derivatization via amide, ester, or acyl chloride formation. The compound exhibits good bench stability and facilitates efficient incorporation into complex molecular architectures through standard coupling reactions.

Synthesis

Route1
- 869722-94-1
- ~78%
- In-stock
  
  920501-51-5
References
- Gan, Zongjie; Zhang, Di; Cao, Zhe; Xu, Yungen Journal of Chemical Research, 2011 , vol. 35, # 6 p. 317 - 319
Route2
- 62985-34-6
- ~%
- In-stock
  
  920501-51-5
References
- Gan, Zongjie; Zhang, Di; Cao, Zhe; Xu, Yungen Journal of Chemical Research, 2011 , vol. 35, # 6 p. 317 - 319

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 37.3
LogP 1.9401
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Key Words

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6-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid

CAS No. 920501-51-5

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