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CS-W001157 4
Total: USD 88.00

3,4-Dichlorobenzaldehyde

  • CAS No. 6287-38-3

  • Cat. No. CS-W007504
  • Purity≥98%
  • MDL No.MFCD00003351

*For research and further manufacturing use only, not for direct human use.

3,4-Dichlorobenzaldehyde|CS-W007504

Structure of 6287-38-3

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General Information

  • CAS No. 6287-38-3
  • Cat. No. CS-W007504
  • Purity ≥98%
  • MDL No. MFCD00003351
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂O
  • Molecular Weight 175.01
  • Synonym(s) N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylbutane-1,4-diamine; 3,4-Dichlorobenzaldehyde
  • SMILES O=CC1=CC=C(Cl)C(Cl)=C1

Description

3,4-Dichlorobenzaldehyde offers a sterically unhindered aldehyde handle flanked by two electron-withdrawing chlorine atoms, enabling efficient coupling reactions. This bench-stable compound integrates readily into synthetic sequences requiring halogenated aromatic aldehydes.

Application

3,4-Dichlorobenzaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic research. Its electron-withdrawing dichloro substituents enhance electrophilicity at the carbonyl carbon, facilitating nucleophilic addition reactions such as imine formation and aldol-type condensations. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for use in multistep syntheses of heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Xu, Liang; Trudell, Mark L. Tetrahedron Letters, 2003 , vol. 44, # 12 p. 2553 - 2555
  • Route2
    • (E)-3,4-dichlorobenzaldehyde oxime|CS-0539886
      5331-92-0
    • ~%
    • In-stock
      3,4-Dichlorobenzaldehyde|CS-W007504
      6287-38-3

    References

    • Applied Catalysis A: General, , vol. 466, p. 282 - 292
  • Route3
    • null|null
      1162648-58-9
    • ~88%
    • In-stock
      3,4-Dichlorobenzaldehyde|CS-W007504
      6287-38-3

    References

    • Shirini; Mashhadi-Nejad Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 3 p. 376 - 381

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8059
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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