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CS-W001157 4
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H-Thr-OMe hydrochloride

  • CAS No. 39994-75-7

  • Cat. No. CS-W008086
  • Purity≥95%
  • MDL No.MFCD00037677

*For research and further manufacturing use only, not for direct human use.

H-Thr-OMe hydrochloride|CS-W008086

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General Information

  • CAS No. 39994-75-7
  • Cat. No. CS-W008086
  • Purity ≥95%
  • MDL No. MFCD00037677
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO₃
  • Molecular Weight 169.61
  • Synonym(s) L-Threonine methyl ester hydrochloride
  • SMILES N[C@H](C(OC)=O)[C@@H](C)O.Cl

Description

H-Thr-OMe (hydrochloride) is a bench-stable, moisture-tolerant N-terminal amino acid derivative featuring a methyl ester group at the C-terminus. This protected threonine variant integrates seamlessly into peptide synthesis workflows, offering reliable coupling efficiency and minimal side-product formation under standard conditions.

Application

H-Thr-OMe (hydrochloride) serves as a stable, bench-ready building block for peptide synthesis, offering a protected threonine side chain with orthogonal functionality. Its methyl ester group enables straightforward amidation and derivatization, while the hydrochloride salt enhances solubility and handling. The molecule facilitates efficient coupling in standard Fmoc-SPPS protocols and supports incorporation into complex peptide scaffolds without significant epimerization.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   -0.7107
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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