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CS-W001157 4
Total: USD 88.00

2-(9H-Fluoren-9-yl)acetic acid

  • CAS No. 6284-80-6

  • Cat. No. CS-0144028
  • Purity≥98%
  • MDL No.MFCD00013262

*For research and further manufacturing use only, not for direct human use.

2-(9H-Fluoren-9-yl)acetic acid|CS-0144028

Structure of 6284-80-6

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General Information

  • CAS No. 6284-80-6
  • Cat. No. CS-0144028
  • Purity ≥98%
  • MDL No. MFCD00013262
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₂O₂
  • Molecular Weight 224.25
  • Synonym(s) 9H-fluoren-9-ylacetic acid
  • SMILES O=C(O)CC1C2=C(C3=C1C=CC=C3)C=CC=C2

Description

This fluorenyl-substituted acetic acid serves as a robust protecting group for carboxylic acids in peptide synthesis. The fluoren-9-yl moiety enables efficient removal under mild basic conditions, minimizing side reactions. Its stability under standard reaction protocols and compatibility with diverse functional groups streamline synthetic workflows.

Application

2-(9H-Fluoren-9-yl)acetic acid serves as a robust, bench-stable building block for solid-phase peptide synthesis and bioconjugation. Its fluorenyl group provides excellent solubility and facilitates efficient removal via mild base-induced cleavage, while the carboxylic acid functionality enables direct coupling to amines under standard activation conditions. The structure exhibits high functional group tolerance and compatibility with diverse reaction environments, making it a reliable choice for synthesizing peptide derivatives and targeted probes.

Synthesis

  • Route1
    • null|null
      87656-19-7
    • ~96%
    • In-stock
      2-(9H-Fluoren-9-yl)acetic acid|CS-0144028
      6284-80-6

    References

    • Oku, Akira; Yokoyama, Taka-aki; Harada, Toshiro Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5333 - 5337
  • Route2
    • Ethyl 2-(9H-fluoren-9-yl)acetate|CS-0324259
      159803-52-8
    • ~90%
    • In-stock
      2-(9H-Fluoren-9-yl)acetic acid|CS-0144028
      6284-80-6

    References

    • Goehring, R. Richard Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 476 - 478
  • Route3

    References

    • Organic Preparations and Procedures International, , vol. 26, # 4 p. 476 - 478

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.2736
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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