Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Chlorobutyronitrile

  • CAS No. 628-20-6

  • Cat. No. CS-D1161
  • Purity≥98%
  • MDL No.MFCD00001972

*For research and further manufacturing use only, not for direct human use.

4-Chlorobutyronitrile|CS-D1161

Structure of 628-20-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 628-20-6
  • Cat. No. CS-D1161
  • Purity ≥98%
  • MDL No. MFCD00001972
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆ClN
  • Molecular Weight 103.55
  • Synonym(s) None
  • SMILES N#CCCCCl

Description

4-Chlorobutyronitrile is a versatile synthetic intermediate featuring a chlorine atom at the γ-position relative to a nitrile group. This arrangement enables selective functionalization in pharmaceutical and agrochemical synthesis, offering enhanced reactivity for nucleophilic substitution or elimination pathways under standard conditions. The molecule combines high stability with predictable transformation behavior.

Application

4-Chlorobutyronitrile serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and bioactive intermediates. Its terminal nitrile and β-chloroalkyl functionalities offer orthogonal reactivity for nucleophilic substitution, cyclization, and transition-metal-catalyzed coupling processes. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • 4-Chlorobutanamide|CS-0660671
      2455-04-1
    • ~87%
    • In-stock
      4-Chlorobutyronitrile|CS-D1161
      628-20-6

    References

    • Heck, Marie-Pierre; Wagner, Alain; Mioskowski, Charles Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6486 - 6487
  • Route2

    References

    • Smushkevich, Y. I.; Smushkevich, V. Y.; Usorov, M. I. Journal of Chemical Research, Miniprint, 1999 , # 7 p. 1727 - 1736
  • Route3
    • null|null
      109-70-6
    • ~%
    • In-stock
      4-Chlorobutyronitrile|CS-D1161
      628-20-6

    References

    • Journal of the American Chemical Society, , vol. 46, p. 1884 Journal of the American Chemical Society, , vol. 51, p. 1186 Org.Synth.Coll.Vol.I<1932>,150; deutsche Ausgabe,S.149 Chemische Berichte, , vol. 23, p. 1771 Chemische Berichte, , vol. 42, p. 1252,Anm.2 Journal of the American Chemical Society, , vol. 63, p. 1733,1736

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3276
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H301-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   23.79
  • LogP   1.52898
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Chlorobutyronitrile sigma4-Chlorobutyronitrile manufacturer4-Chlorobutyronitrile price4-Chlorobutyronitrile structure4-Chlorobutyronitrile SDSbuy 4-Chlorobutyronitrile4-Chlorobutyronitrile supplier4-Chlorobutyronitrile uses4-Chlorobutyronitrile molecular weightprice of 4-Chlorobutyronitrile4-Chlorobutyronitrile chemical name formula of 4-Chlorobutyronitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label