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CS-W001157 4
Total: USD 88.00

Triethyl methanetricarboxylate

  • CAS No. 6279-86-3

  • Cat. No. CS-W002047
  • Purity≥98%
  • MDL No.MFCD00009150

*For research and further manufacturing use only, not for direct human use.

Triethyl methanetricarboxylate|CS-W002047

Structure of 6279-86-3

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General Information

  • CAS No. 6279-86-3
  • Cat. No. CS-W002047
  • Purity ≥98%
  • MDL No. MFCD00009150
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆O₆
  • Molecular Weight 232.23
  • Synonym(s) Triethyl Carboxymalonate; Triethyl methanetricarboxylate
  • SMILES CCOC(=O)C(C(=O)OCC)C(=O)OCC

Description

Triethyl methanetricarboxylate features three ester groups flanking a central carbon, enabling efficient multicomponent reactions. This electron-deficient triester integrates readily into synthetic sequences, offering high reactivity under mild conditions. The molecule's symmetry and steric profile support clean functionalization, making it ideal for constructing complex carbocycles and heterocycles in medicinal chemistry workflows.

Application

Triethyl methanetricarboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted malonate derivatives and heterocyclic scaffolds. Its three ester groups provide orthogonal reactivity for sequential functionalization, while the central methylene unit offers high nucleophilicity for alkylation and condensation reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step syntheses in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      541-41-3
    • null|null
      105-53-3
    • ~72%
    • In-stock
      Triethyl methanetricarboxylate|CS-W002047
      6279-86-3

    References

    • Santra, Santimukul; Kumar, Anil Chemical Communications, 2004 , # 18 p. 2126 - 2127
  • Route2
    • null|null
      16515-85-8
    • ~80%
    • In-stock
      Triethyl methanetricarboxylate|CS-W002047
      6279-86-3

    References

    • Yamazaki, Takanori; Urabe, Hirokazu; Sato, Fumie Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 7 p. 1673 - 1681
  • Route3
    • null|null
      543-27-1
    • ~1%
    • In-stock
      Triethyl methanetricarboxylate|CS-W002047
      6279-86-3
    • null|null
      125563-02-2
    • null|null
      125563-03-3

    References

    • Tetrahedron, , vol. 45, # 14 p. 4593 - 4598

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.9
  • LogP   0.2919
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   6

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