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CS-W001157 4
Total: USD 88.00

2,5-Dimethylpyrrole

  • CAS No. 625-84-3

  • Cat. No. CS-W011343
  • Purity≥96%
  • MDL No.MFCD00005223

*For research and further manufacturing use only, not for direct human use.

2,5-Dimethylpyrrole|CS-W011343

Structure of 625-84-3

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General Information

  • CAS No. 625-84-3
  • Cat. No. CS-W011343
  • Purity ≥96%
  • MDL No. MFCD00005223
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N
  • Molecular Weight 95.14
  • Synonym(s) None
  • SMILES CC1=CC=C(C)N1

Description

2,5-Dimethyl-1H-pyrrole offers a sterically hindered, electron-rich pyrrolic scaffold ideal for constructing functionalized heterocycles. This bench-stable compound integrates readily into synthetic sequences requiring robust nitrogen-containing motifs, particularly in medicinal chemistry and materials science applications.

Application

2,5-Dimethyl-1H-pyrrole serves as a valuable building block in heterocyclic synthesis, offering enhanced stability and defined regiochemistry for downstream functionalization. Its methyl substituents at the 2- and 5-positions facilitate selective electrophilic substitution and enable efficient coupling reactions, particularly in Pd-catalyzed transformations. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it a practical scaffold for medicinal chemistry and process development workflows.

Synthesis

  • Route1
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      628-16-0
    • ~96%
    • In-stock
      2,5-Dimethylpyrrole|CS-W011343
      625-84-3

    References

    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Patent: WO2009/137810 A2, 2009 ; Location in patent: Page/Page column 21; 2/13 ;
  • Route2
    • null|null
      625-86-5
    • ~%
    • In-stock
      2,5-Dimethylpyrrole|CS-W011343
      625-84-3

    References

    • DE706095 , ; DRP/DRBP Org.Chem.
  • Route3

    References

    • Cranwell, Philippa B.; O'Brien, Matthew; Browne, Duncan L.; Koos, Peter; Polyzos, Anastasios; Pena-Lopez, Miguel; Ley, Steven V. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5774 - 5779

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS06
Signal Word : Danger
UN#: 1992
Class : 3 (6.1)
Packing Group : Ⅲ
Hazard Statements : H226-H301+H311+H331-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   1.63154
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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