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5-Bromothiophene-3-carbaldehyde

  • CAS No. 18791-79-2

  • Cat. No. CS-0050554
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromothiophene-3-carbaldehyde|CS-0050554

Structure of 18791-79-2

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General Information

  • CAS No. 18791-79-2
  • Cat. No. CS-0050554
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrOS
  • Molecular Weight 191.05
  • Synonym(s) 5-Bromothiophene-3-carboxaldehyde
  • SMILES BrC1=CC(C=O)=CS1

Description

5-Bromothiophene-3-carbaldehyde features a brominated thiophene ring fused to an aldehyde group, enabling direct functionalization in cross-coupling and condensation reactions. The electron-deficient thiophene core enhances reactivity in palladium-catalyzed transformations, while the aldehyde moiety serves as a versatile handle for further derivatization. This bench-stable compound integrates efficiently into complex molecular architectures under standard conditions.

Application

5-Bromothiophene-3-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the thiophene core. Its aldehyde group facilitates nucleophilic additions and condensation reactions, while the bromine substituent supports palladium-catalyzed cross-couplings. The molecule exhibits bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis of heterocyclic scaffolds and advanced intermediates in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H317-H319-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3231
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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