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CS-W001157 4
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Benzyl (3R)-3-methylpiperazine-1-carboxylate

  • CAS No. 623586-00-5

  • Cat. No. CS-0028238
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl (3R)-3-methylpiperazine-1-carboxylate|CS-0028238

Structure of 623586-00-5

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General Information

  • CAS No. 623586-00-5
  • Cat. No. CS-0028238
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈N₂O₂
  • Molecular Weight 234.29
  • Synonym(s) (R)-benzyl 3-methylpiperazine-1-carboxylate
  • SMILES O=C(N1C[C@@H](C)NCC1)OCC2=CC=CC=C2

Description

Benzyl (3R)-3-methylpiperazine-1-carboxylate is a stereochemically defined piperazine derivative featuring a chiral methyl group at the 3-position. This configuration enhances its utility in asymmetric synthesis and medicinal chemistry applications. The benzyl ester moiety offers convenient protection and orthogonal handling, enabling selective deprotection under mild conditions. Its bench-stable nature supports reliable use in multi-step transformations and process development workflows.

Application

Benzyl (3R)-3-methylpiperazine-1-carboxylate serves as a chiral building block for medicinal chemistry and catalytic synthesis. The (3R)-configured piperazine core enables stereoselective transformations, while the benzyl ester facilitates convenient deprotection under mild hydrogenolysis conditions. This compound exhibits excellent bench stability, functional group tolerance, and compatibility with standard coupling protocols, making it ideal for constructing complex heterocyclic scaffolds in API development.

Synthesis

  • Route1
    • In-stock
      (R)-2-Methylpiperazine|CS-W020739
      75336-86-6
    • null|null
      501-53-1
    • ~%
    • In-stock
      Benzyl (3R)-3-methylpiperazine-1-carboxylate|CS-0028238
      623586-00-5

    References

    • US2006/84640 A1, ; Page/Page column 15 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6169
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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