[(2S,4R)-4-Fluoropyrrolidin-2-yl]methanol;hydrochloride

Name: [(2S,4R)-4-Fluoropyrrolidin-2-yl]methanol;hydrochloride
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CAS No. 623583-09-5
Cat. No. CS-0035888
Molecule weight155.60
Purity≥97%
MDL No.None

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[(2S,4R)-4-Fluoropyrrolidin-2-yl]methanol;hydrochloride|CS-0035888

Structure of 623583-09-5

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General Information

CAS No. 623583-09-5
Cat. No. CS-0035888
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁ClFNO
Molecular Weight 155.60
Synonym(s) ((2s,4r)-4-Fluoropyrrolidin-2-yl)methanol hydrochloride
SMILES OC[C@H]1NC[C@H](F)C1.Cl

Description

This fluorinated pyrrolidinemethanol hydrochloride features a stereochemically defined chiral center, offering enhanced metabolic stability and favorable solubility. The (2S,4R) configuration supports precise molecular recognition in medicinal chemistry applications. The hydrochloride salt improves handling and shelf-life under standard conditions.

Application

[(2S,4R)-4-Fluoropyrrolidin-2-yl]methanol hydrochloride serves as a stereochemically defined building block for fluorinated pyrrolidine scaffolds prevalent in medicinal chemistry. The hydrochloride salt enhances bench stability and solubility, enabling straightforward incorporation into amide couplings, reductive aminations, and nucleophilic displacements. Its fluorine substituent imparts metabolic stability and modulates electronic properties, making it valuable for optimizing bioactive molecule profiles in CNS-targeted and kinase inhibitor programs.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 32.26
LogP 0.1005
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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[(2S,4R)-4-Fluoropyrrolidin-2-yl]methanol;hydrochloride

CAS No. 623583-09-5

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