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CS-W001157 4
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Ethyl 3-Hydroxypropanoate

  • CAS No. 623-72-3

  • Cat. No. CS-0139545
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-Hydroxypropanoate|CS-0139545

Structure of 623-72-3

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General Information

  • CAS No. 623-72-3
  • Cat. No. CS-0139545
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃
  • Molecular Weight 118.13
  • Synonym(s) propanoic acid, 3-hydroxy-, ethyl ester
  • SMILES O=C(OCC)CCO

Description

Ethyl 3-hydroxypropanoate features a β-hydroxy ester motif enabling direct incorporation into polyol scaffolds and macrolide syntheses. This bench-stable, moisture-tolerant reagent facilitates efficient C–C bond formation under mild conditions, serving as a key intermediate in the construction of bioactive cyclic ethers and complex natural product analogs.

Application

Ethyl 3-hydroxypropanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to γ-hydroxy esters and related heterocycles. Its hydroxyl and ester functionalities support orthogonal transformations, including selective derivatization, cyclization reactions, and metal-catalyzed coupling processes. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Chem. Zentralbl., , vol. 87, # I p. 143 Chem. Zentralbl., , vol. 86, # I p. 527
  • Route2
    • null|null
      64-17-5
    • null|null
      97674-27-6
    • ~64%
    • In-stock
      Ethyl 3-Hydroxypropanoate|CS-0139545
      623-72-3

    References

    • Keul, Helmut; Choi, Hyung-Soo; Kuczkowski, Robert L. Journal of Organic Chemistry, 1985 , vol. 50, # 18 p. 3365 - 3371
  • Route3
    • In-stock
      Propiolactone|CS-0030919
      57-57-8
    • null|null
      1067-41-0
    • ~12%
    • In-stock
      Ethyl 3-Hydroxypropanoate|CS-0139545
      623-72-3
    • null|null
      80109-34-8

    References

    • Journal of the American Chemical Society, , vol. 103, # 24 p. 7339 - 7340

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.0681
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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