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CS-W001157 4
Total: USD 88.00

(5-Methoxy-2-methylphenyl)boronic acid

  • CAS No. 617689-07-3

  • Cat. No. CS-W018771
  • Purity≥95%
  • MDL No.MFCD03425973

*For research and further manufacturing use only, not for direct human use.

(5-Methoxy-2-methylphenyl)boronic acid|CS-W018771

Structure of 617689-07-3

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General Information

  • CAS No. 617689-07-3
  • Cat. No. CS-W018771
  • Purity ≥95%
  • MDL No. MFCD03425973
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₃
  • Molecular Weight None
  • Synonym(s) 5-Methoxy-2-methyl benzeneboronic acid
  • SMILES COC1=CC(B(O)O)=C(C)C=C1

Description

This boronic acid features a methoxy-substituted aromatic ring paired with a methyl group at the ortho position, enhancing electronic and steric control. The pendant boronate moiety enables efficient Suzuki-Miyaura coupling under standard conditions, offering reliable cross-coupling performance in synthetic workflows requiring stable, electron-rich arylboron reagents.

Application

(5-Methoxy-2-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-substituted arylboronic acid structure provides enhanced stability and predictable reactivity, facilitating the construction of complex biaryl architectures. The methoxy and methyl groups offer complementary electronic and steric modulation, improving functional group tolerance and simplifying purification. This reagent is well-suited for pharmaceutical and agrochemical synthesis workflows requiring bench-stable, high-purity intermediates.

Synthesis

  • Route1

    References

    • TargeGen, Inc. Patent: US2005/245524 A1, 2005 ; Location in patent: Page/Page column 98-99 ; US 20050245524 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.31658
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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