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CS-W001157 4
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(S)-3-Aminobutan-1-ol

  • CAS No. 61477-39-2

  • Cat. No. CS-W019851
  • Purity≥97%
  • MDL No.MFCD08275763

*For research and further manufacturing use only, not for direct human use.

(S)-3-Aminobutan-1-ol|CS-W019851

Structure of 61477-39-2

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General Information

  • CAS No. 61477-39-2
  • Cat. No. CS-W019851
  • Purity ≥97%
  • MDL No. MFCD08275763
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁NO
  • Molecular Weight 89.14
  • Synonym(s) 1-Butanol, 3-amino-, (S)-; 1-Fmoc-4-(Cbz-amino)piperidine-4-carboxylic acid; (S)-3-Aminobutan-1-ol
  • SMILES C[C@H](N)CCO

Description

(S)-3-Aminobutan-1-ol is a chiral building block featuring a primary alcohol and a secondary amine separated by a two-carbon chain. This configuration enables selective functionalization in asymmetric synthesis, particularly in the development of bioactive molecules and peptide mimetics. The stereogenic center ensures high enantioselectivity in downstream transformations.

Application

(S)-3-Aminobutan-1-ol serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through established amine-functionalized scaffolds. Its well-defined stereochemistry supports stereoselective transformations, while the primary alcohol and secondary amine groups offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for use in multi-step syntheses and API development workflows.

Synthesis

  • Route1
    • (S)-Benzyl (4-hydroxybutan-2-yl)carbamate|CS-0727164
      168827-91-6
    • ~91%
    • In-stock
      (S)-3-Aminobutan-1-ol|CS-W019851
      61477-39-2

    References

    • F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BODIL VAN NIEL, Monique; FAUBER, Benjamin; GAINES, Simon; GOBBI, Alberto; RENE, Olivier; VESEY, David; WARD, Stuart Patent: WO2014/9447 A1, 2014 ; Location in patent: Page/Page column 96; 97 ;
  • Route2
    • Methyl 3-aminobutanoate|CS-0147335
      6078-06-4
    • ~14%
    • In-stock
      (S)-3-Aminobutan-1-ol|CS-W019851
      61477-39-2

    References

    • Studer, Martin; Burkhardt, Stefan; Blaser, Hans-Ulrich Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 802 - 808
  • Route3
    • null|null
      61477-38-1
    • ~%
    • In-stock
      (S)-3-Aminobutan-1-ol|CS-W019851
      61477-39-2

    References

    • The Journal of organic chemistry, , vol. 42, # 9 p. 1650 - 1652

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.284
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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