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CS-W001157 4
Total: USD 88.00

1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine

  • CAS No. 614730-97-1

  • Cat. No. CS-W000442
  • Purity≥95%
  • MDL No.MFCD08062513

*For research and further manufacturing use only, not for direct human use.

1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine|CS-W000442

Structure of 614730-97-1

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General Information

  • CAS No. 614730-97-1
  • Cat. No. CS-W000442
  • Purity ≥95%
  • MDL No. MFCD08062513
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀FNO₃
  • Molecular Weight 233.28
  • Synonym(s) Tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
  • SMILES OCC1(F)CCN(CC1)C(=O)OC(C)(C)C

Description

1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine features a bench-stable Boc-protected piperidine core with a fluorine atom and a hydroxymethyl group positioned at the 4-position. This combination enables direct incorporation into complex molecular architectures, particularly in medicinal chemistry scaffolds requiring stereocontrolled functionalization and metabolic stability.

Application

1-Boc-4-fluoro-4-(hydroxymethyl)piperidine serves as a versatile building block for medicinal chemistry, enabling efficient access to fluorinated piperidine scaffolds. The Boc group provides stability and facilitates selective deprotection, while the hydroxymethyl functionality supports downstream derivatization via oxidation or substitution. Its compatibility with standard coupling and protection protocols makes it ideal for modular synthesis of bioactive molecules.

Synthesis

  • Route1

    References

    • AC Immune S.A. Patent: EP2377860 A1, 2011 ; Location in patent: Page/Page column 26 ;
  • Route2

    References

    • CANCER RESEARCH TECHNOLOGY LIMITED Patent: WO2009/44162 A1, 2009 ; Location in patent: Page/Page column 247 ; WO 2009/044162 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.7179
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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