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CS-W001157 4
Total: USD 88.00

Indan, 4-bromo-

  • CAS No. 6134-53-8

  • Cat. No. CS-0028240
  • Purity≥98%
  • MDL No.MFCD22059711

*For research and further manufacturing use only, not for direct human use.

Indan, 4-bromo-|CS-0028240

Structure of 6134-53-8

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General Information

  • CAS No. 6134-53-8
  • Cat. No. CS-0028240
  • Purity ≥98%
  • MDL No. MFCD22059711
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉Br
  • Molecular Weight 197.07
  • Synonym(s) 1H-Indene,4-bromo-2,3-dihydro
  • SMILES BrC1=CC=CC2=C1CCC2

Description

4-Bromo-2,3-dihydro-1H-indene is a brominated indene derivative featuring a reactive alkene moiety and a pendant bromine at the 4-position. This structure enables direct incorporation into cross-coupling reactions and serves as a key intermediate in the synthesis of functionalized aromatic systems. The molecule exhibits stability under standard bench conditions and compatibility with transition metal catalysis.

Application

4-Bromo-2,3-dihydro-1H-indene serves as a versatile building block in medicinal chemistry and synthetic organic research. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the dihydroindene core provides a rigid, planar scaffold suitable for drug discovery applications. Its bench-stable nature and compatibility with common protecting group strategies facilitate efficient synthesis of complex heterocyclic systems and functionalized aromatic compounds.

Synthesis

  • Route1

    References

    • SANOFI-AVENTIS; GEORGE, Pascal; HALL, Daniel; HARTUNG, Ryan; KOSLEY, JR., Raymond W.; SCOTESE, Anthony C. Patent: WO2011/34828 A1, 2011 ; Location in patent: Page/Page column 44 ; WO 2011/034828 A1
  • Route2

    References

    • Gruber, Rene; Cagniant, Denise; Cagniant, Paul Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 3-4 p. 96 - 104
  • Route3

    References

    • Kon; Woolman Journal of the Chemical Society, 1939 , p. 794,797 Full Text Show Details Fieser; Seligman Journal of the American Chemical Society, 1935 , vol. 57, p. 2174

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.9378
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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