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CS-W001157 4
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(S)-2-Amino-N-methylpropanamide hydrochloride

  • CAS No. 61275-22-7

  • Cat. No. CS-0169314
  • Purity≥97%
  • MDL No.MFCD00237739

*For research and further manufacturing use only, not for direct human use.

(S)-2-Amino-N-methylpropanamide hydrochloride|CS-0169314

Structure of 61275-22-7

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General Information

  • CAS No. 61275-22-7
  • Cat. No. CS-0169314
  • Purity ≥97%
  • MDL No. MFCD00237739
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁ClN₂O
  • Molecular Weight 138.60
  • Synonym(s) propanamide, 2-amino-N-methyl-, (2S)-
  • SMILES C[C@H](N)C(NC)=O.Cl

Description

This chiral amide derivative features a stereodefined (S)-configuration at the α-carbon, enhancing its utility in asymmetric synthesis. The N-methyl substitution improves metabolic stability and membrane permeability, while the hydrochloride salt form ensures high solubility and ease of handling under standard conditions.

Application

(S)-2-Amino-N-methylpropanamide hydrochloride serves as a chiral building block for peptide synthesis and bioactive molecule construction. Its well-defined stereochemistry enables stereoselective coupling reactions, while the amide and ammonium functionalities offer versatility in downstream derivatization. The hydrochloride salt enhances solubility and stability, facilitating handling and purification in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      84851-00-3
    • ~98%
    • In-stock
      (S)-2-Amino-N-methylpropanamide hydrochloride|CS-0169314
      61275-22-7

    References

    • Shendage, Deepak M.; Froehlich, Roland; Haufe, Guenter Organic Letters, 2004 , vol. 6, # 21 p. 3675 - 3678
  • Route2

    References

    • Samulis, Leopold; Tomkinson, Nicholas C.O. Tetrahedron, 2011 , vol. 67, # 23 p. 4263 - 4267
  • Route3
    • In-stock
      L-Alanine methyl ester hydrochloride|CS-W008772
      2491-20-5
    • null|null
      74-89-5
    • ~%
    • In-stock
      (S)-2-Amino-N-methylpropanamide hydrochloride|CS-0169314
      61275-22-7

    References

    • Organic Syntheses, , vol. 88, p. 42 - 53

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.4986
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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