Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

6-Chloro-2-methyl-1H-indole

  • CAS No. 6127-17-9

  • Cat. No. CS-W023086
  • Purity≥97%
  • MDL No.MFCD09027716

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methyl-1H-indole|CS-W023086

Structure of 6127-17-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6127-17-9
  • Cat. No. CS-W023086
  • Purity ≥97%
  • MDL No. MFCD09027716
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClN
  • Molecular Weight 165.62
  • Synonym(s) 6-CHLORO-2-METHYLINDOLE
  • SMILES CC(N1)=CC2=C1C=C(Cl)C=C2

Description

6-Chloro-2-methyl-1H-indole is a bench-stable, electron-deficient indole derivative featuring a chloro group at the 6-position and a methyl substituent at the 2-position. This substitution pattern enhances regioselectivity in electrophilic aromatic substitution reactions and supports efficient incorporation into bioactive heterocycles.

Application

6-Chloro-2-methyl-1H-indole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling reactions. Its electron-deficient indole core enhances reactivity in electrophilic substitutions, while the methyl group provides steric control and metabolic stability. Bench-stable and readily purified by flash chromatography, it functions effectively in the synthesis of kinase inhibitors, CNS-targeted compounds, and other heterocyclic scaffolds requiring halogenated indoles.

Synthesis

  • Route1
    • (6-Chloro-1H-indol-2-yl)methanol|CS-0453366
      53590-58-2
    • ~27%
    • In-stock
      6-Chloro-2-methyl-1H-indole|CS-W023086
      6127-17-9

    References

    • Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick Patent: US2007/27163 A1, 2007 ; Location in patent: Page/Page column 22 ; US 20070027163 A1
  • Route2
    • null|null
      163688-23-1
    • ~%
    • In-stock
      6-Chloro-2-methyl-1H-indole|CS-W023086
      6127-17-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 8 p. 2684 - 2690
  • Route3
    • (3-Chlorophenyl)hydrazine hydrochloride|CS-W017297
      2312-23-4
    • ~%
    • In-stock
      6-Chloro-2-methyl-1H-indole|CS-W023086
      6127-17-9

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 1 p. 135 - 158

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.12972
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6-Chloro-2-methyl-1H-indole sigma6-Chloro-2-methyl-1H-indole manufacturer6-Chloro-2-methyl-1H-indole price6-Chloro-2-methyl-1H-indole structure6-Chloro-2-methyl-1H-indole SDSbuy 6-Chloro-2-methyl-1H-indole6-Chloro-2-methyl-1H-indole supplier6-Chloro-2-methyl-1H-indole uses6-Chloro-2-methyl-1H-indole molecular weightprice of 6-Chloro-2-methyl-1H-indole6-Chloro-2-methyl-1H-indole chemical name formula of 6-Chloro-2-methyl-1H-indole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label