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CS-W001157 4
Total: USD 88.00

2-Iodo-4,5-dimethoxybenzoic acid

  • CAS No. 61203-48-3

  • Cat. No. CS-0112938
  • Purity≥96%
  • MDL No.MFCD00079751

*For research and further manufacturing use only, not for direct human use.

2-Iodo-4,5-dimethoxybenzoic acid|CS-0112938

Structure of 61203-48-3

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General Information

  • CAS No. 61203-48-3
  • Cat. No. CS-0112938
  • Purity ≥96%
  • MDL No. MFCD00079751
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉IO₄
  • Molecular Weight 308.07
  • Synonym(s) 4,5-Dimethoxy-2-iodobenzoic acid
  • SMILES O=C(O)C1=CC(OC)=C(OC)C=C1I

Application

2-Iodo-4,5-dimethoxybenzoic acid serves as a versatile building block for Suzuki-Miyaura and Stille coupling reactions, enabling efficient construction of biaryl scaffolds in medicinal chemistry. The iodine moiety provides high reactivity under standard palladium catalysis, while the dimethoxy substituents offer predictable electronic modulation and enhanced solubility. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring ortho-functionalized aromatic intermediates.

Synthesis

  • Route1

    References

    • WO2012/15875 A1, ; Page/Page column 57 ;
  • Route2
    • 2-Iodo-4,5-dimethoxybenzaldehyde|CS-0365087
      61203-53-0
    • ~10%
    • In-stock
      2-Iodo-4,5-dimethoxybenzoic acid|CS-0112938
      61203-48-3

    References

    • Heterocycles, , vol. 49, # 1 p. 191 - 195
  • Route3

    References

    • Tetrahedron Letters, , vol. 44, # 17 p. 3483 - 3486

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   2.0066
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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