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CS-W001157 4
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5-Methoxy-7-methyl-1H-indole

  • CAS No. 61019-05-4

  • Cat. No. CS-0114970
  • Purity≥98%
  • MDL No.MFCD09027022

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-7-methyl-1H-indole|CS-0114970

Structure of 61019-05-4

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General Information

  • CAS No. 61019-05-4
  • Cat. No. CS-0114970
  • Purity ≥98%
  • MDL No. MFCD09027022
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO
  • Molecular Weight 161.20
  • Synonym(s) None
  • SMILES CC1=CC(OC)=CC2=C1NC=C2

Description

5-Methoxy-7-methyl-1H-indole features a substituted indole core with electron-donating methoxy and methyl groups at the 5- and 7-positions, respectively. This configuration enhances stability and modulates reactivity for use in pharmaceutical intermediates and bioactive molecule synthesis. The compound exhibits favorable solubility and bench-stability under standard conditions.

Application

5-Methoxy-7-methyl-1H-indole serves as a valuable heterocyclic building block in medicinal chemistry, enabling efficient access to indole-based scaffolds. Its electron-rich core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The methoxy and methyl groups provide orthogonal functional handles for further derivatization, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis and API development workflows.

Synthesis

  • Route1

    References

    • Glennon, R. A.; Schubert, E.; Jacyno, J. M.; Rosecrans, J. A. Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1222 - 1226
  • Route2
    • 4-Methoxy-2-methylaniline|CS-W016518
      102-50-1
    • ~%
    • In-stock
      5-Methoxy-7-methyl-1H-indole|CS-0114970
      61019-05-4

    References

    • Journal of Medicinal Chemistry, , vol. 23, # 11 p. 1222 - 1226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.48492
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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