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CS-W001157 4
Total: USD 88.00

5-Methoxy-3-methyl-1H-indole

  • CAS No. 21987-25-7

  • Cat. No. CS-0436714
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-3-methyl-1H-indole|CS-0436714

Structure of 21987-25-7

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General Information

  • CAS No. 21987-25-7
  • Cat. No. CS-0436714
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO
  • Molecular Weight 161.20
  • Synonym(s) YSOFHURJVUIKMU-UHFFFAOYSA
  • SMILES CC1=CNC2=C1C=C(OC)C=C2

Description

5-Methoxy-3-methyl-1H-indole features a substituted indole core with a methoxy group at C5 and a methyl substituent at C3, conferring enhanced solubility and stability. This electron-rich scaffold integrates readily into bioactive molecule design, particularly in pharmaceutical intermediates and fluorescent probes.

Application

5-Methoxy-3-methyl-1H-indole serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indole scaffolds. Its methoxy and methyl groups provide orthogonal functional handles for further derivatization, while the core indole framework exhibits favorable stability and solubility profiles. The compound functions effectively in standard coupling reactions and facilitates rapid diversification in API development workflows.

Synthesis

  • Route1
    • null|null
      93816-90-1
    • ~85%
    • In-stock
      5-Methoxy-3-methyl-1H-indole|CS-0436714
      21987-25-7

    References

    • Trost, Barry M.; Quancard, Jean Journal of the American Chemical Society, 2006 , vol. 128, # 19 p. 6314 - 6315
  • Route2
    • null|null
      111795-96-1
    • ~75%
    • In-stock
      5-Methoxy-3-methyl-1H-indole|CS-0436714
      21987-25-7

    References

    • Makosza, Mieczyslaw; Danikiewicz, Witold; Wojciechowski, Krzysztof Liebigs Annalen der Chemie, 1988 , p. 203 - 208
  • Route3
    • null|null
      1308803-37-3
    • ~72%
    • In-stock
      5-Methoxy-3-methyl-1H-indole|CS-0436714
      21987-25-7

    References

    • Okuro, Kazumi; Gurnham, Joanna; Alper, Howard Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4715 - 4720

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.48492
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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