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Total: USD 88.00

4-Methoxybenzene-1,3-diol

  • CAS No. 6100-60-3

  • Cat. No. CS-0031177
  • Purity≥98%
  • MDL No.MFCD00210443

*For research and further manufacturing use only, not for direct human use.

4-Methoxybenzene-1,3-diol|CS-0031177

Structure of 6100-60-3

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General Information

  • CAS No. 6100-60-3
  • Cat. No. CS-0031177
  • Purity ≥98%
  • MDL No. MFCD00210443
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₃
  • Molecular Weight 140.14
  • Synonym(s) 1,3-Benzenediol, 4-methoxy-
  • SMILES OC1=CC=C(OC)C(O)=C1

Description

4-Methoxybenzene-1,3-diol features a phenolic backbone with strategically positioned hydroxyl and methoxy groups, enabling enhanced solubility and redox stability. This combination supports efficient participation in coupling reactions and facilitates integration into complex molecular architectures under standard bench conditions.

Application

4-Methoxybenzene-1,3-diol serves as a versatile phenolic building block in medicinal chemistry and materials science. Its ortho-dihydroxy arrangement enables chelation and oxidation-sensitive transformations, while the para-methoxy group enhances solubility and modulates electronic properties. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it a practical scaffold for synthesizing bioactive heterocycles and functional polymers.

Synthesis

  • Route1

    References

    • Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
  • Route2
    • null|null
      1324054-65-0
    • ~39%
    • In-stock
      4-Methoxybenzene-1,3-diol|CS-0031177
      6100-60-3

    References

    • N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WASLEY, Jan Patent: WO2011/99978 A1, 2011 ; Location in patent: Page/Page column 43-44 ; WO 2011/099978 A1
  • Route3
    • null|null
      1083312-69-9
    • ~%
    • In-stock
      4-Methoxybenzene-1,3-diol|CS-0031177
      6100-60-3

    References

    • US2011/82098 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.1064
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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