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CS-W001157 4
Total: USD 88.00

1-Methylindolin-2-one

  • CAS No. 61-70-1

  • Cat. No. CS-W013308
  • Purity≥98%
  • MDL No.MFCD00030253

*For research and further manufacturing use only, not for direct human use.

1-Methylindolin-2-one|CS-W013308

Structure of 61-70-1

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General Information

  • CAS No. 61-70-1
  • Cat. No. CS-W013308
  • Purity ≥98%
  • MDL No. MFCD00030253
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.18
  • Synonym(s) N-Methyloxindole
  • SMILES O=C1N(C)C2=C(C=CC=C2)C1

Application

1-Methylindolin-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient construction of biologically relevant heterocycles. Its indolinone core exhibits excellent bench stability and functions as a key building block for Suzuki-Miyaura couplings, amide formations, and late-stage functionalizations. The methyl group at the nitrogen enhances solubility and modulates reactivity, facilitating purification and scalability in multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      Oxindole|CS-M2997
      59-48-3
    • null|null
      77-78-1
    • 1-Methyl-5-sulfanyl-2,3-dihydro-1h-indol-2-one|CS-0256776
      166883-22-3
    • ~%
    • In-stock
      1-Methylindolin-2-one|CS-W013308
      61-70-1

    References

    • US5478842 A1, ; US 5478842 A
  • Route2
    • null|null
      52209-63-9
    • ~62%
    • In-stock
      1-Methylindolin-2-one|CS-W013308
      61-70-1

    References

    • Tsukano, Chihiro; Okuno, Masataka; Takemoto, Yoshiji Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2763 - 2766
  • Route3
    • null|null
      36558-96-0
    • ~75%
    • In-stock
      1-Methylindolin-2-one|CS-W013308
      61-70-1
    • 2,2-Dichloro-N-methyl-N-phenylacetamide|CS-1014324
      23496-29-9

    References

    • Tetrahedron Letters, , vol. 35, # 51 p. 9553 - 9556

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.2055
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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