Lot numbers can be found on the outside label of a product:
Benzyl 2-amino-2-methylpropanoate hydrochloride
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CAS No. 60421-20-7
- Cat. No. CS-0096008
- Purity≥97%
- MDL No.MFCD14155677
*For research and further manufacturing use only, not for direct human use.
Structure of 60421-20-7
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General Information
- CAS No. 60421-20-7
- Cat. No. CS-0096008
- Purity ≥97%
- MDL No. MFCD14155677
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₆ClNO₂
- Molecular Weight 229.70
- Synonym(s) 2-amino-2-methyl-propionic acid benzyl ester hydrochloride
- SMILES CC(C)(N)C(OCC1=CC=CC=C1)=O.[H]Cl
Description
Benzyl 2-amino-2-methylpropanoate hydrochloride is a bench-stable, moisture-tolerant amino acid derivative featuring a sterically hindered α-carbon and a protected amine. This compound integrates readily into peptide synthesis workflows, serving as a key intermediate for constructing constrained peptidomimetics and bioactive scaffolds under standard conditions.
Application
Benzyl 2-amino-2-methylpropanoate hydrochloride serves as a versatile building block in peptide and heterocyclic synthesis, offering a stable, bench-ready source of the tert-leucine-derived amino group. Its tertiary α-amino functionality enables efficient coupling reactions with minimal racemization, while the benzyl ester facilitates straightforward deprotection under standard hydrogenolysis conditions. The hydrochloride salt enhances solubility and crystallinity, simplifying handling and purification in synthetic workflows.
Synthesis
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Route1
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55456-40-1 - ~59%
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In-stock
60421-20-7
References
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VALEANT RESEARCH and DEVELOPMENT Patent: WO2006/121820 A1, 2006 ; Location in patent: Page/Page column 15-16 ;
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Route2
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84758-57-6 - ~%
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In-stock
60421-20-7
References
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Kissei Pharmaceutical Co., Ltd. Patent: EP1544208 A1, 2005 ; Location in patent: Page/Page column 62-63 ;
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Route3
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62-57-7 -
In-stock
100-51-6 - ~60%
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In-stock
60421-20-7
References
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Roche Palo Alto LLC Patent: US2007/42988 A1, 2007 ; Location in patent: Page/Page column 18; 21 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 52.32
- LogP 1.8889
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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