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CS-W001157 4
Total: USD 88.00

2-Amino-3-hydroxynitrobenzene

  • CAS No. 603-85-0

  • Cat. No. CS-W008642
  • Purity≥97%
  • MDL No.MFCD00010875

*For research and further manufacturing use only, not for direct human use.

2-Amino-3-hydroxynitrobenzene|CS-W008642

Structure of 603-85-0

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General Information

  • CAS No. 603-85-0
  • Cat. No. CS-W008642
  • Purity ≥97%
  • MDL No. MFCD00010875
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) None
  • SMILES OC1=C(C([N+]([O-])=O)=CC=C1)N

Application

2-Amino-3-hydroxynitrobenzene serves as a versatile building block in heterocyclic synthesis and medicinal chemistry, enabling efficient access to substituted quinoline and isoquinoline scaffolds. Its complementary amino, hydroxyl, and nitro functionalities exhibit robust reactivity in coupling, cyclization, and reduction processes, with good bench stability and straightforward purification via recrystallization or column chromatography.

Synthesis

  • Route1
    • 2-Acetamidophenyl acetate|CS-0574808
      5467-64-1
    • ~%
    • In-stock
      2-Amino-3-hydroxynitrobenzene|CS-W008642
      603-85-0

    References

    • Journal of the Chemical Society, , p. 1057
  • Route2
    • null|null
      66-56-8
    • ~%
    • 3-Amino-2-nitrophenol|CS-0542375
      14703-71-0
    • In-stock
      2-Amino-3-hydroxynitrobenzene|CS-W008642
      603-85-0

    References

    • Journal of Organic Chemistry USSR (English Translation), , vol. 27, # 1 p. 21 - 31 Zhurnal Organicheskoi Khimii, , vol. 27, # 1 p. 24 - 35
  • Route3
    • In-stock
      4-Nitro-1,3-benzoxazole|CS-0213301
      163808-13-7
    • ~0%
    • In-stock
      2-Amino-3-hydroxynitrobenzene|CS-W008642
      603-85-0
    • null|null
      163298-74-6

    References

    • Katritzky, Alan R.; Musgrave, Richard P.; Rachwal, Bogumila; Zaklika, Chris Heterocycles, 1995 , vol. 41, # 2 p. 345 - 352

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   89.39
  • LogP   0.8826
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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