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CS-W001157 4
Total: USD 88.00

H-D-Homoser-OH

  • CAS No. 6027-21-0

  • Cat. No. CS-W011215
  • Purity≥97%
  • MDL No.MFCD00077786

*For research and further manufacturing use only, not for direct human use.

H-D-Homoser-OH|CS-W011215

Structure of 6027-21-0

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General Information

  • CAS No. 6027-21-0
  • Cat. No. CS-W011215
  • Purity ≥97%
  • MDL No. MFCD00077786
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO₃
  • Molecular Weight 119.12
  • Synonym(s) None
  • SMILES N[C@H](CCO)C(O)=O

Description

H-D-Homoser-OH delivers a stable, bioactive homoserine derivative featuring a protected hydroxyl group and a D-configured chiral center. This compound integrates readily into peptide synthesis workflows, enabling efficient access to modified serine and threonine analogs under standard conditions.

Application

H-D-Homoser-OH serves as a key chiral building block in the synthesis of β-hydroxy amino acids and related heterocyclic scaffolds. Its well-defined stereochemistry and bench-stable hydroxyl group enable reliable coupling reactions and selective transformations, facilitating efficient access to bioactive intermediates in medicinal chemistry and peptide-based drug discovery.

Synthesis

  • Route1
    • (R)-(3-amino-3-carboxypropyl)dimethylsulfonium iodide|CS-0516250
      3493-10-5
    • ~99%
    • In-stock
      H-D-Homoser-OH|CS-W011215
      6027-21-0

    References

    • Jamieson, Andrew G.; Boutard, Nicolas; Beauregard, Kim; Bodas, Mandar S.; Ong, Huy; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 7917 - 7927
  • Route2
    • (3R)-3-Amino-3-(furan-2-yl)propan-1-ol|CS-0748404
      206194-18-5
    • ~30%
    • In-stock
      H-D-Homoser-OH|CS-W011215
      6027-21-0

    References

    • Koriyama, Yuji; Nozawa, Akihiro; Hayakawa, Ryuuichirou; Shimizu, Makoto Tetrahedron, 2002 , vol. 58, # 47 p. 9621 - 9628
  • Route3

    References

    • Shiraiwa, Tadashi; Miyazaki, Hideya; Ohta, Atsushi; Waki, Yukitaka; Yasuda, Masahiro; Morishita, Toshimitsu; Kurokawa, Hidemoto Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 12 p. 2322 - 2325

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   -1.2193
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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