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CS-W001157 4
Total: USD 88.00

1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride

  • CAS No. 6000-50-6

  • Cat. No. CS-W003872
  • Molecule weight193.08
  • Purity≥97%
  • MDL No.MFCD15144657

*For research and further manufacturing use only, not for direct human use.

1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride|CS-W003872

Structure of 6000-50-6

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General Information

  • CAS No. 6000-50-6
  • Cat. No. CS-W003872
  • Purity ≥97%
  • MDL No. MFCD15144657
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀Cl₂N₂
  • Molecular Weight 193.08
  • Synonym(s) 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine dihydrochloride
  • SMILES C12=CN=CC=C1CNC2.Cl.Cl

Description

1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride is a heterocyclic scaffold featuring a fused pyrrole-pyridine core with two protonated nitrogen sites. This bench-stable salt delivers enhanced solubility in aqueous and polar organic media, enabling efficient integration into synthetic routes for medicinal chemistry applications. The dihydrochloride form ensures improved crystallinity and handling stability during purification and storage.

Application

1H,2H,3H-Pyrrolo[3,4-c]pyridine dihydrochloride serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its rigid fused-ring structure provides enhanced metabolic stability and favorable binding interactions in target-directed compound libraries. The dihydrochloride salt enhances solubility and handling, enabling efficient incorporation into Suzuki-Miyaura, Buchwald-Hartwig, and other cross-coupling reactions. Functions reliably as a core scaffold in the development of kinase inhibitors and CNS-targeted therapeutics.

Synthesis

  • Route1
    • Ethyl 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate|CS-0097965
      147740-04-3
    • ~%
    • In-stock
      1H,2H,3H-pyrrolo[3,4-c]pyridine dihydrochloride|CS-W003872
      6000-50-6

    References

    • US5312823 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.5284
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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