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CS-W001157 4
Total: USD 88.00

Hexamethonium chloride

  • CAS No. 60-25-3

  • Cat. No. CS-0013618
  • Molecule weight273.29
  • Purity≥98%
  • MDL No.MFCD00031563

*For research and further manufacturing use only, not for direct human use.

Hexamethonium chloride|CS-0013618

Structure of 60-25-3

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General Information

  • CAS No. 60-25-3
  • Cat. No. CS-0013618
  • Purity ≥98%
  • MDL No. MFCD00031563
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₃₀Cl₂N₂
  • Molecular Weight 273.29
  • Synonym(s) Hexone (chloride)
  • SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Cl-].[Cl-]

Description

Blocking nicotinic acetylcholine receptor signaling at the neuromuscular junction, Hexamethonium chloride (CAS 60-25-3) inhibits ion flux through ligand-gated channels by stabilizing the closed conformation of α-subunit interfaces.

Application

Hexamethonium chloride (CAS 60-25-3) blocks nicotinic receptor responses to agonists by acting as a potent competitive antagonist at neuronal junctions. This enables precise control over autonomic signaling. Researchers leverage this property to dissect mechanosensitivity in viscerofugal neurons, revealing key pathways in visceral sensory processing.

Synthesis

  • Route1

    References

    • Chemistry - A European Journal, , vol. 5, # 4 p. 1284 - 1290

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   0
  • LogP   -4.0328
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   7

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