Pyrazolo[1,5-a]pyridin-2(1H)-one

Name: Pyrazolo[1,5-a]pyridin-2(1H)-one
Brand: ChemScene
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CAS No. 59942-87-9
Cat. No. CS-W000669
Purity≥97%
MDL No.MFCD09878924

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Pyrazolo[1,5-a]pyridin-2(1H)-one|CS-W000669

Structure of 59942-87-9

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Description

Pyrazolo[1,5-a]pyridin-2(1H)-one is a heterocyclic scaffold featuring a fused pyrazole and pyridine ring system with a lactam functionality. This electron-deficient core enables robust integration into bioactive molecules, particularly in kinase inhibitors and targeted therapeutics. The compound exhibits bench-stable behavior and compatibility with diverse synthetic transformations.

Application

Pyrazolo[1,5-a]pyridin-2(1H)-one serves as a privileged heterocyclic scaffold in medicinal chemistry, offering structural rigidity and hydrogen-bonding capacity via its lactam carbonyl and imine nitrogen. It functions as a key building block in the synthesis of kinase inhibitors and other bioactive molecules, demonstrating compatibility with standard coupling reactions and robust bench stability. Its well-defined reactivity profile enables straightforward functionalization at multiple positions, facilitating rapid diversification for structure-activity studies.

General Information

CAS No. 59942-87-9
Cat. No. CS-W000669
Purity ≥97%
MDL No. MFCD09878924
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆N₂O
Molecular Weight 134.14
Synonym(s) Pyrazolo[1,5-a]pyridin-2-ol
SMILES O=C1NN2C=CC=CC2=C1

Computational Chemistry Data

TPSA 32.34
LogP 0.2758
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Pyrazolo[1,5-a]pyridin-2(1H)-one

CAS No. 59942-87-9

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