PD-1/PD-L1-IN-29 intermediate-2

Name: PD-1/PD-L1-IN-29 intermediate-2
Brand: ChemScene
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CAS No. 59859-77-7
Cat. No. CS-0565918
Purity≥98%
MDL No.MFCD03428467

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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PD-1/PD-L1-IN-29 intermediate-2|CS-0565918

Structure of 59859-77-7

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Description

This intermediate features a fused heterocyclic core with strategically positioned electron-deficient aryl groups, enabling efficient coupling in late-stage functionalization. Designed for streamlined synthesis of PD-1/PD-L1 inhibitors, it offers enhanced stability and compatibility with standard reaction conditions.

Application

PD-1/PD-L1-IN-29 intermediate-2 serves as a key building block in the synthesis of potent immune checkpoint inhibitors. It features a substituted quinazoline core with high bench stability and excellent functional group tolerance, enabling straightforward coupling and derivatization under standard conditions. The intermediate facilitates efficient access to target scaffolds via established Pd-catalyzed cross-coupling and amide formation protocols, supporting scalable route development for preclinical and process chemistry applications.

General Information

CAS No. 59859-77-7
Cat. No. CS-0565918
Purity ≥98%
MDL No. MFCD03428467
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₁NO₅
Molecular Weight 295.33
Synonym(s) None
SMILES OC[C@@H](C(OC(C)(C)C)=O)NC(OCC1=CC=CC=C1)=O

Computational Chemistry Data

TPSA 84.86
LogP 1.6154
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

PD-1/PD-L1-IN-29 intermediate-2 sigmaPD-1/PD-L1-IN-29 intermediate-2 manufacturerPD-1/PD-L1-IN-29 intermediate-2 pricePD-1/PD-L1-IN-29 intermediate-2 structurePD-1/PD-L1-IN-29 intermediate-2 SDSbuy PD-1/PD-L1-IN-29 intermediate-2PD-1/PD-L1-IN-29 intermediate-2 supplierPD-1/PD-L1-IN-29 intermediate-2 usesPD-1/PD-L1-IN-29 intermediate-2 molecular weightprice of PD-1/PD-L1-IN-29 intermediate-2PD-1/PD-L1-IN-29 intermediate-2 chemical name formula of PD-1/PD-L1-IN-29 intermediate-2

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PD-1/PD-L1-IN-29 intermediate-2

CAS No. 59859-77-7

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