Fmoc-Ser-OtBu

Name: Fmoc-Ser-OtBu
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 110797-35-8
Cat. No. CS-0040463
Purity≥95%
MDL No.MFCD01861331

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

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Description

Fmoc-Ser-OtBu is a protected serine derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group at the α-amino position and a tert-butyl ester at the side-chain hydroxyl. This combination enables efficient incorporation into peptide chains under standard solid-phase synthesis conditions, offering excellent solubility and stability during sequential coupling steps.

Application

Fmoc-Ser-OtBu serves as a cornerstone building block in peptide synthesis, enabling efficient N-terminal protection and side-chain stabilization of serine residues. Its bench-stable Fmoc group facilitates orthogonal deprotection in solid-phase workflows, while the OtBu ester protects the hydroxyl functionality against unwanted reactions. The compound exhibits excellent solubility in common organic solvents and tolerates diverse coupling conditions, making it ideal for routine and scale-up applications in peptide and peptidomimetic assembly.

General Information

CAS No. 110797-35-8
Cat. No. CS-0040463
Purity ≥95%
MDL No. MFCD01861331
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₂₅NO₅
Molecular Weight 383.44
Synonym(s) None
SMILES OC[C@@H](C(OC(C)(C)C)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Computational Chemistry Data

TPSA 84.86
LogP 3.2277
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Glycoscience Reagents for Oligosaccharide Synthesis

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-Ser-OtBu

CAS No. 110797-35-8

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