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CS-W001157 4
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2-Bromo-6-chloroaniline

  • CAS No. 59772-49-5

  • Cat. No. CS-0042752
  • Purity≥96%
  • MDL No.MFCD11977383

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-chloroaniline|CS-0042752

Structure of 59772-49-5

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General Information

  • CAS No. 59772-49-5
  • Cat. No. CS-0042752
  • Purity ≥96%
  • MDL No. MFCD11977383
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrClN
  • Molecular Weight 206.47
  • Synonym(s) 2-Bromo-6-chlorobenzenamine
  • SMILES NC1=C(Cl)C=CC=C1Br

Description

L-Glutamic acid monosodium salt is used as a flavor enhancer, swine feed additive as well as to improve the taste of bitter drugs. It is used therapeutically to reduce blood ammonia levels. It serves as an excitatory amino acid neurotransmitter, which is an agonist at glur and NMDA receptors. Further, it is used to reduce the intake of sodium.

Application

2-Bromo-6-chloroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles via standard coupling reactions. Its ortho-halogenated structure facilitates directed metallation and palladium-catalyzed cross-couplings, while the aniline functionality offers tunable reactivity for derivatization. Bench-stable and readily purified by recrystallization, it supports scalable synthesis workflows with predictable regioselectivity.

Synthesis

  • Route1
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      95-51-2
    • ~%
    • In-stock
      2-Bromo-6-chloroaniline|CS-0042752
      59772-49-5
    • In-stock
      4-Bromo-2-chlorophenylamine|CS-W020030
      38762-41-3

    References

    • Krishna Mohan; Narender; Srinivasu; Kulkarni; Raghavan Synthetic Communications, 2004 , vol. 34, # 12 p. 2143 - 2152
  • Route2

    References

    • Morrison, Matthew D.; Hanthorn, Jason J.; Pratt, Derek A. Organic Letters, 2009 , vol. 11, # 5 p. 1051 - 1054
  • Route3
    • null|null
      90493-87-1
    • ~66%
    • In-stock
      2-Bromo-6-chloroaniline|CS-0042752
      59772-49-5

    References

    • Ayyangar, N. R.; Kalkote, U. R.; Nikrad, P. V. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 9 p. 872 - 877

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332
Precautionary Statements : P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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